Xyrem

The treatment of Narcolepsy including Sodium Oxybate (Xyrem) and Modafinil

Narcolepsy is one of the most complex of non-respiratory Sleep Disorders, consisting of a tetrad was Excessive Daytime Sleepiness, Cataplexy, Sleep Paralysis and Hypnagogic Hallucinations. Once we’ve diagnosed Narcolepsy, treatment for your Narcolepsy comes in many forms including :

Behavioral Therapy

Good sleep hygiene is crucial in managing Narcolepsy symptoms in the long term. Adequate sleep at night is important, daytime timed-naps can be useful.

Medications

Many medications can be used to treat Narcolepsy, each with their own pros and cons.

CNS stimulants such as Methylphenidate (Ritalin, Concerta) and dextroamphetamine (dexamphetamine, dexamfetamine) work well but have long term complications. Pemoline is less commonly used due to the potential side effects.

Modafinil and Armodafinil (Modavigil, Nuvigil) are generally better-tolerated than amphetamine-based medications, and with less side effects. These still however require longterm vigilance.

Sodium oxybate (Xyrem, metabolite of gamma-aminobutyric acid) has been used in the USA since 2002, and has been used by our clinic since it’s Australian approval in late 2014. We have the largest known group of patients in South Australia on treatment, with impressive symptomatic results. We provide continuous regular clinical monitoring in conjunction with patients’ General Practitioners, to ensure optimal titration of treatment modalities based on the patient’s current clinical status.

At Adelaide Sleep, we routinely counsel, diagnose, and treat all aspects of Narcolepsy and Idiopathic Hypersomnia. We have experience in all medications used for Narcolepsy and Narcolepsy-like conditions. If you’d like to know more, contact us now.

© APSS 2018